From http://www.w3schools.com (Copyright Refsnes Data)

ASP.NET - Events

An Event Handler is a subroutine that executes code for a given event.

ASP.NET - Event Handlers

Look at the following code:

<%
lbl1.Text="The date and time is " & now()
%>

<html>
<body>
<form runat="server">
<h3><asp:label id="lbl1" runat="server" /></h3>
</form>
</body>
</html>

When will the code above be executed? The answer is: "You don't know..."

The Page_Load Event

The Page_Load event is one of many events that ASP.NET understands. The Page_Load event is triggered when a page loads, and ASP.NET will automatically call the subroutine Page_Load, and execute the code inside it:

<script runat="server">
Sub Page_Load
lbl1.Text="The date and time is " & now()
End Sub
</script>

<html>
<body>
<form runat="server">
<h3><asp:label id="lbl1" runat="server" /></h3>
</form>
</body>
</html>

Note: The Page_Load event contains no object references or event arguments!

Example

The Page.IsPostBack Property

The Page_Load subroutine runs EVERY time the page is loaded. If you want to execute the code in the Page_Load subroutine only the FIRST time the page is loaded, you can use the Page.IsPostBack property. If the Page.IsPostBack property is false, the page is loaded for the first time, if it is true, the page is posted back to the server (i.e. from a button click on a form):

<script runat="server">
Sub Page_Load
if Not Page.IsPostBack then
  lbl1.Text="The date and time is " & now()
end if
End Sub

Sub submit(s As Object, e As EventArgs)
lbl2.Text="Hello World!"
End Sub
</script>

<html>
<body>
<form runat="server">
<h3><asp:label id="lbl1" runat="server" /></h3>
<h3><asp:label id="lbl2" runat="server" /></h3>
<asp:button text="Submit" onclick="submit" runat="server" />
</form>
</body>
</html>

The example above will write the "The date and time is...." message only the first time the page is loaded. When a user clicks on the Submit button, the submit subroutine will write "Hello World!" to the second label, but the date and time in the first label will not change.

Example